Emergent bistability by a growth-modulating positive feedback circuit
نویسندگان
چکیده
منابع مشابه
Emergent bistability by a growth-modulating positive feedback circuit.
Synthetic gene circuits are often engineered by considering the host cell as an invariable 'chassis'. Circuit activation, however, may modulate host physiology, which in turn can substantially impact circuit behavior. We illustrate this point by a simple circuit consisting of mutant T7 RNA polymerase (T7 RNAP*) that activates its own expression in the bacterium Escherichia coli. Although activa...
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Cell signaling systems that contain positive-feedback loops or double-negative feedback loops can, in principle, convert graded inputs into switch-like, irreversible responses. Systems of this sort are termed "bistable". Recently, several groups have engineered artificial bistable systems into Escherichia coli and Saccharomyces cerevisiae, and have shown that the systems exhibit interesting and...
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ژورنال
عنوان ژورنال: Nature Chemical Biology
سال: 2009
ISSN: 1552-4450,1552-4469
DOI: 10.1038/nchembio.218